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MAI-400

Chemical Structure : MAI-400

CAS No.: 2250328-65-3

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MAI-400 (MAI400, MAI 400)

Catalog No.: PC-35569Not For Human Use, Lab Use Only.

MAI-400 (MAI400) is a novel peptide inhibitor of APC-Asef interaction with Kd of 12 nM and IC50 of 0.25 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MAI-400 (MAI400) is a novel peptide inhibitor of APC-Asef interaction with Kd of 12 nM and IC50 of 0.25 uM.
    MAI-400 effectively blocks the APC-Asef interaction in cell lysates in a dose-dependent manner.
    MAI-400 decreases the association of cellular APC protein with cellular Asef in a dose-dependent manner.

    Physicochemical Properties

    M.Wt 900.94
    Formula C41H56N8O15
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (4S,7S,10S,13S,16S)-16-(2-((S)-2-(((benzyloxy)carbonyl)amino)propanamido)acetamido)-4-carbamoyl-7-(4-hydroxybenzyl)-13-(hydroxymethyl)-10-isobutyl-6,9,12,15-tetraoxo-5,8,11,14-tetraazanonadecanedioic acid

    References

    1. Yang X, et al. J Med Chem. 2018 Aug 10. doi: 10.1021/acs.jmedchem.8b01112.

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