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MAL3-101

Chemical Structure : MAL3-101

CAS No.: 912361-26-3

MAL3-101 (MAL 3-101)

Catalog No.: PC-62566Not For Human Use, Lab Use Only.

MAL3-101 is a Hsc70 modulator that inhibits Hsp70 ATPase activity, exhibits antiproliferative activity in breast cancer cells SK-BR-3 with IC50 of 27 uM.

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    Biological Activity

    MAL3-101 is a Hsc70 modulator that inhibits Hsp70 ATPase activity, exhibits antiproliferative activity in breast cancer cells SK-BR-3 with IC50 of 27 uM.
    MAL3-101 also exhibits antimyeloma effects on MM cell lines in vitro and in vivo in a xenograft plasmacytoma model, as well as on primary tumor cells and bone marrow endothelial cells from myeloma patients.

    Physicochemical Properties

    M.Wt 931.14
    Formula C54H66N4O10
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    5-Pyrimidinecarboxylic acid, 4-[1,1'-biphenyl]-2-yl-1-[6-[[2-(butylamino)-1-[3-(methoxycarbonyl)-4-(2-methoxy-2-oxoethoxy)phenyl]-2-oxoethyl]hexylamino]-6-oxohexyl]-1,2,3,4-tetrahydro-6-methyl-2-oxo-, phenylmethyl ester

    References

    1. Fewell SW, et al. J Biol Chem. 2004 Dec 3;279(49):51131-40.

    2. Huryn DM, et al. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6757-62.

    3. Braunstein MJ, et al. J Oncol. 2011;2011:232037. doi: 10.1155/2011/232037.

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