MASP-2 inhibitor 22

Chemical Structure : MASP-2 inhibitor 22

Catalog No.: PC-24087Not For Human Use, Lab Use Only.

MASP-2 inhibitor 22 is a potent, specific small-molecule inhibitor of mannan-binding lectin-associated serine proteases -2 (MASP-2) with IC50 of 8.9 nM, >40-fold selective over MASP-3.

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Biological Activity

MASP-2 inhibitor 22 is a potent, specific small-molecule inhibitor of mannan-binding lectin-associated serine proteases -2 (MASP-2) with IC50 of 8.9 nM, >40-fold selective over MASP-3.

Physicochemical Properties

M.Wt	462.53
Formula	C23H22N6O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(2-amino-1H-imidazole-4-yl)benzyl)-2-(6-(phenylsulfonamido)pyridin-3-yl)acetamide

References

1. Nakhla MC, et al. Eur J Med Chem. 2025 Jan 9;289:117238.

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