MASP-2 inhibitor 77

Chemical Structure : MASP-2 inhibitor 77

Catalog No.: PC-24086Not For Human Use, Lab Use Only.

MASP-2 inhibitor 77 is a potent, specific small-molecule inhibitor of mannan-binding lectin-associated serine proteases -2 (MASP-2) with IC50 of 11.2 nM, >100-fold selective over MASP-3.

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Biological Activity

MASP-2 inhibitor 77 is a potent, specific small-molecule inhibitor of mannan-binding lectin-associated serine proteases -2 (MASP-2) with IC50 of 11.2 nM, >100-fold selective over MASP-3.
MASP-2 inhibitor 77 is selective over other serine proteases and possesses attractive physiochemical and ADMET properties.

Physicochemical Properties

M.Wt	463.52
Formula	C22H21N7O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(2-amino-1H-imidazole-4-yl)benzyl)-2-(5-(phenylsulfonamido)pyrimidin-2-yl)acetamide

References

1. Nakhla MC, et al. Eur J Med Chem. 2025 Jan 9;289:117238.

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