Chemical Structure : MAT2A inhibitor 28
CAS No.: 2439271-82-4
Catalog No.: PC-72337Not For Human Use, Lab Use Only.
MAT2A inhibitor 28 (AZ-28) is a potent and selective inhibitor of methionine adenosyltransferase MAT2A with IC50 of 22 nM.
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MAT2A inhibitor 28 (AZ-28) is a potent and selective inhibitor of methionine adenosyltransferase MAT2A with IC50 of 22 nM.
MAT2A inhibitor 28 showed inhibition of PRMT5-mediated symmetric dimethylation of arginine (SDMA) with IC50 of 25 nM, inhibited proliferation of HCT116 MTAP knockout cells with an IC50 of 250 nM.
MAT2A inhibitor 28 is a promising in vivo tool that exhibited reduction in tumor SAM levels and antitumor response in an MTAP knockout HCT116 xenograft model.
M.Wt | 299.758 | |
Formula | C16H14ClN3O | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
2(1H)-Quinazolinone, 7-chloro-4-(dimethylamino)-1-phenyl- |
1. Claudia De Fusco, et al. J Med Chem. 2021 May 27;64(10):6814-6826.
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