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MAT2A inhibitor 28

Chemical Structure : MAT2A inhibitor 28

CAS No.: 2439271-82-4

MAT2A inhibitor 28 (AZ-28, MAT2A inhibitor 3)

Catalog No.: PC-72337Not For Human Use, Lab Use Only.

MAT2A inhibitor 28 (AZ-28) is a potent and selective inhibitor of methionine adenosyltransferase MAT2A with IC50 of 22 nM.

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Biological Activity

MAT2A inhibitor 28 (AZ-28) is a potent and selective inhibitor of methionine adenosyltransferase MAT2A with IC50 of 22 nM.
MAT2A inhibitor 28 showed inhibition of PRMT5-mediated symmetric dimethylation of arginine (SDMA) with IC50 of 25 nM, inhibited proliferation of HCT116 MTAP knockout cells with an IC50 of 250 nM.
MAT2A inhibitor 28 is a promising in vivo tool that exhibited reduction in tumor SAM levels and antitumor response in an MTAP knockout HCT116 xenograft model.

Physicochemical Properties

M.Wt 299.758
Formula C16H14ClN3O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2(1H)-Quinazolinone, 7-chloro-4-(dimethylamino)-1-phenyl-

References

1. Claudia De Fusco, et al. J Med Chem. 2021 May 27;64(10):6814-6826.

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