MAT2A inhibitor ZS97

Chemical Structure : MAT2A inhibitor ZS97

Catalog No.: PC-27635Not For Human Use, Lab Use Only.

MAT2A inhibitor ZS97 is a potent, selective and orally bioavailable methionine adenosyltransferase 2A (MAT2A) inhibitor, demonstrates potent enzymatic inhibition, effectively depleting intracellular SAM and suppressing downstream PRMT5-mediated methylation.

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Biological Activity

MAT2A inhibitor ZS97 is a potent, selective and orally bioavailable methionine adenosyltransferase 2A (MAT2A) inhibitor, demonstrates potent enzymatic inhibition, effectively depleting intracellular SAM and suppressing downstream PRMT5-mediated methylation.

Physicochemical Properties

M.Wt	410.23
Formula	C18H12BrN5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-bromo-6-(1H-indazol-4-yl)-9-(methylamino)furo[2,3-f]quinazolin-7(6H)-one

References

1. Lin L, et al. J Med Chem. 2026 Aug 13;69(15):18838-18855.

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