You are here:Home-Chemical Inhibitors & Agonists-Others-Other Targets-MBD2 inhibitor APC
MBD2 inhibitor APC

Chemical Structure : MBD2 inhibitor APC

CAS No.: 1353960-31-2

MBD2 inhibitor APC

Catalog No.: PC-72568Not For Human Use, Lab Use Only.

MBD2 inhibitor APC (APC) is a small molecule inhibitor targeting an intrinsically disordered protein region (IDPR) of MBD2 with antimetastatic activity, inhibits DOT-mediated PPI of MBD2, efficiently disrupts MBD2 interaction with p66α with IC50 of 1.03 uM (FRET).

Packing Price Stock Quantity
10 mg $158 In stock
25 mg $258 In stock
50 mg $428 In stock
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MBD2 inhibitor APC (APC) is a small molecule inhibitor targeting an intrinsically disordered protein region (IDPR) of MBD2 with antimetastatic activity, inhibits DOT-mediated PPI of MBD2, efficiently disrupts MBD2 interaction with p66α with IC50 of 1.03 uM (FRET).
APC suppresses the migration of breast adenocarcinoma MDA-MB-231 (LM1) and colorectal carcinoma HCT116 cells.
APC induces mesenchymal-epithelial transition (MET) on treatment of mesenchymal type of cancer cells.
APC exhibits a potent inhibition of the cancer metastasis to lung in xenograft mice transplanted with the LM1 cells, with no significant effects on body weight.

Physicochemical Properties

M.Wt 243.307
Formula C11H21N3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-(2-amino-acetylamino)-pyrrolidine-1-carboxylic acid tert-butyl ester

References

1. Min Young Kim, et al. Sci Adv. 2019 Nov 20;5(11):eaav9810.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: