MBLAC2 inhibitor KV-65

Chemical Structure : MBLAC2 inhibitor KV-65

Catalog No.: PC-24576Not For Human Use, Lab Use Only.

MBLAC2 inhibitor KV-65 is a potent, specific inhibitor of the metalloenzyme MBLAC2 (Metallo-Beta-Lactamase Domain Containing 2) with EC50 of 37 nM, 64-fold selectivity over HDAC6.

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Biological Activity

MBLAC2 inhibitor KV-65 is a potent, specific inhibitor of the metalloenzyme MBLAC2 (Metallo-Beta-Lactamase Domain Containing 2) with EC50 of 37 nM, 64-fold selectivity over HDAC6.
KV-65 does not affect cell proliferation or fitness at concentrations up to 10 μM, but upregulates extracellular vesicles (EVs) in HEK293 cells.
KV-65 is a valuable tool for elucidating the cell biological functions of MBLAC2.

Physicochemical Properties

M.Wt	380.42
Formula	C20H16N2O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((5,5-dioxido-10H-phenothiazin-10-yl)methyl)-N-hydroxybenzamide

References

1. Severin Lechner, et al. ACS Chem Biol. 2025 May 8. doi: 10.1021/acschembio.5c00108.

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