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MBX-102 acid

Chemical Structure : MBX-102 acid

CAS No.: 23953-39-1

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MBX-102 acid (MBX102 acid)

Catalog No.: PC-49253Not For Human Use, Lab Use Only.

MBX-102 acid is the active form of JNJ39659100 (MBX-102), a selective partial PPAR-γ agonist with EC50 of 23.34 uM (hPPAR-γ), enhances insulin sensitivity in vitro in 3T3-L1 adipocytes, binds to the PPAR-γ LBD in a manner that is distinct from but overlapping with rosiglitazone.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MBX-102 acid is the active form of JNJ39659100 (MBX-102), a selective partial PPAR-γ agonist with EC50 of 23.34 uM (hPPAR-γ), enhances insulin sensitivity in vitro in 3T3-L1 adipocytes, binds to the PPAR-γ LBD in a manner that is distinct from but overlapping with rosiglitazone.

    Physicochemical Properties

    M.Wt 330.687
    Formula C15H10ClF3O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-2-(4-chlorophenyl)-2-(3-(trifluoromethyl)phenoxy)acetic acid

    References

    1. Gregoire FM, et al. Mol Endocrinol. 2009 Jul;23(7):975-88.

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