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MBX-102 acid

Chemical Structure : MBX-102 acid

CAS No.: 23953-39-1

MBX-102 acid

Catalog No.: PC-49253Not For Human Use, Lab Use Only.

MBX-102 acid is the active form of JNJ39659100 (MBX-102), a selective partial PPAR-γ agonist with EC50 of 23.34 uM (hPPAR-γ), enhances insulin sensitivity in vitro in 3T3-L1 adipocytes, binds to the PPAR-γ LBD in a manner that is distinct from but overlapping with rosiglitazone.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MBX-102 acid is the active form of JNJ39659100 (MBX-102), a selective partial PPAR-γ agonist with EC50 of 23.34 uM (hPPAR-γ), enhances insulin sensitivity in vitro in 3T3-L1 adipocytes, binds to the PPAR-γ LBD in a manner that is distinct from but overlapping with rosiglitazone.

Physicochemical Properties

M.Wt 330.687
Formula C15H10ClF3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-2-(4-chlorophenyl)-2-(3-(trifluoromethyl)phenoxy)acetic acid

References

1. Gregoire FM, et al. Mol Endocrinol. 2009 Jul;23(7):975-88.

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