MBX-2366 (ISG-21)

Chemical Structure : MBX-2366

Catalog No.: PC-49003Not For Human Use, Lab Use Only.

MBX-2366 (ISG-21) is a potent and specific antimalarial compound with IC50 of 3 nM (P. falciparum growth inhibition), acts directly on plasmodial surface anion channel (PSAC, Target K0.5=2 nM) to quantitatively abolish parasite-induced permeability changes.

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Biological Activity

MBX-2366 (ISG-21) is a potent and specific antimalarial compound with IC50 of 3 nM (P. falciparum growth inhibition), acts directly on plasmodial surface anion channel (PSAC, Target K0.5=2 nM) to quantitatively abolish parasite-induced permeability changes.

Physicochemical Properties

M.Wt	430.541
Formula	C20H22N4O3S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(5-((4-(2,5-dimethylphenyl)piperazin-1-yl)sulfonyl)thiophen-2-yl)pyridazin-3(2H)-one

References

1. Michelle M Butler, et al. Mol Pharmacol. 2022 Jul 7;MOLPHARM-AR-2022-000549.

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MBX-2366 (ISG-21)

Biological Activity

Physicochemical Properties

References

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