Catalog No.: PC-49005Not For Human Use, Lab Use Only.
MBX-4055 is a potent and specific antimalarial compound with IC50 of 42 nM (P. falciparum growth inhibition), acts directly on plasmodial surface anion channel (PSAC, Target K0.5=21 nM) to quantitatively abolish parasite-induced permeability changes.
MBX-4055 is a potent and specific antimalarial compound with IC50 of 42 nM (P. falciparum growth inhibition), acts directly on plasmodial surface anion channel (PSAC, Target K0.5=21 nM) to quantitatively abolish parasite-induced permeability changes.
MBX-4055 is active against divergent human parasite strains, with improved oral absorption with acceptable in vivo tolerability and pharmacokinetics.
MBX-4055 is highly specific for the PSAC target without activity against a battery of human channels, enzymes and receptors, is refractory to acquired resistance during extended in vitro selection.
