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Chemical Structure : MCC-555
CAS No.: 161600-01-7
Catalog No.: PC-62431Not For Human Use, Lab Use Only.
MCC-555 (Isaglitazone, Netoglitazone, RWJ 241947) is an activating ligand of PPARγ with EC50 of 8 uM, exhibts greater antidiabetic potency that other TZDs including BRL49653.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $228 | In stock | |
| 50 mg | $378 | In stock | |
| 100 mg | Get quote |
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MCC-555 (Isaglitazone, Netoglitazone, RWJ 241947) is an activating ligand of PPARγ with EC50 of 8 uM, exhibts greater antidiabetic potency that other TZDs including BRL49653.
MCC-555 (Isaglitazone, Netoglitazone, RWJ 241947) profoundly suppresses growth of PC-3 prostate cancer xenografts with prominent apoptosis, as well as fibrosis, including inflammatory and giant cell reaction in the remaining tumor tissue.
| M.Wt | 381.421 | |
| Formula | C21H16FNO3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-[[6-[(2-fluorophenyl)methoxy]-2-naphthalenyl]methyl]-2,4-thiazolidinedione |
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1. Reginato MJ, et al. J Biol Chem. 1998 Dec 4;273(49):32679-84.
2. Kumagai T, et al. Clin Cancer Res. 2004 Feb 15;10(4):1508-20.
3. Cekanova M, et al. Eur J Pharmacol. 2010 Jul 10;637(1-3):30-7.
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