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MCC-555

Chemical Structure : MCC-555

CAS No.: 161600-01-7

MCC-555 (Isaglitazone, Netoglitazone, RWJ 241947, MCC555)

Catalog No.: PC-62431Not For Human Use, Lab Use Only.

MCC-555 (Isaglitazone, Netoglitazone, RWJ 241947) is an activating ligand of PPARγ with EC50 of 8 uM, exhibts greater antidiabetic potency that other TZDs including BRL49653.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MCC-555 (Isaglitazone, Netoglitazone, RWJ 241947) is an activating ligand of PPARγ with EC50 of 8 uM, exhibts greater antidiabetic potency that other TZDs including BRL49653.
MCC-555 (Isaglitazone, Netoglitazone, RWJ 241947) profoundly suppresses growth of PC-3 prostate cancer xenografts with prominent apoptosis, as well as fibrosis, including inflammatory and giant cell reaction in the remaining tumor tissue.

Physicochemical Properties

M.Wt 381.421
Formula C21H16FNO3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-[[6-[(2-fluorophenyl)methoxy]-2-naphthalenyl]methyl]-2,4-thiazolidinedione

References

1. Reginato MJ, et al. J Biol Chem. 1998 Dec 4;273(49):32679-84.

2. Kumagai T, et al. Clin Cancer Res. 2004 Feb 15;10(4):1508-20.

3. Cekanova M, et al. Eur J Pharmacol. 2010 Jul 10;637(1-3):30-7.

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