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MCI-INI-3

Chemical Structure : MCI-INI-3

CAS No.: 1011366-31-6

MCI-INI-3

Catalog No.: PC-72799Not For Human Use, Lab Use Only.

MCI-INI-3 is a potent, selective, competitive inhibitor of ALDH1A3 (Ki=0.55 uM, shows poor inhibitory effect on the structurally related isoform ALDH1A1 (>140-fold selectivity).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MCI-INI-3 is a potent, selective, competitive inhibitor of ALDH1A3 (Ki=0.55 uM), shows poor inhibitory effect on the structurally related isoform ALDH1A1 (>140-fold selectivity).
MCI-INI-3 also displays on inhibition against six isoforms of ALDH (ALDH16A1, ALDH7A1, ALDH9A1, ALDH2, ALDH1B1, ALDH18A1).
MCI-INI-3 demonstrates selective binding to ALDH1A3 in glioma stem cell lysates, inhibits ALDH activity and affects RA synthesis in cells.

Physicochemical Properties

M.Wt 373.368
Formula C21H15N3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

methyl 5-(benzo[d][1,3]dioxol-5-yl)-2-phenylpyrazolo[1,5-a]pyrimidine-7-carboxylate

References

1. Jianfeng Li, et al. Commun Biol. 2021 Dec 21;4(1):1420.

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