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MCL0020

Chemical Structure : MCL0020

CAS No.: 475498-26-1

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MCL0020 (MCL 0020)

Catalog No.: PC-21480Not For Human Use, Lab Use Only.

MCL0020 is a potent, selective inverse agonist of melanocortin MC4 receptor (MC4R) with binding IC50 of 11.6 nM, shows negligible affinity for MC1 and MC3 receptors.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MCL0020 is a potent, selective inverse agonist of melanocortin MC4 receptor (MC4R) with binding IC50 of 11.6 nM, shows negligible affinity for MC1 and MC3 receptors.
MCL0020 attenuates swim stress-induced anxiogeniclike behavior in light/dark exploration tests in mice, significantly reverses stress-induced anorexia in rats.

Physicochemical Properties

M.Wt 609.72
Formula C34H39N7O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-Acetyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-3-(2-naphthalenyl)-L-alaninamide

References

1. Chaki S, et al. Eur J Pharmacol. 2003 Aug 1;474(1):95-101.

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