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Chemical Structure : MCL0129
Catalog No.: PC-61570Not For Human Use, Lab Use Only.
MCL0129 is a selective, potent melanocortin-4 receptor (MC4R) antagonist with Ki of 7.9 nM, without affinity for MC1 and MC3.
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MCL0129 is a selective, potent melanocortin-4 receptor (MC4R) antagonist with Ki of 7.9 nM, without affinity for MC1 and MC3.
MCL0129 attenuates the alpha-MSH-increased cAMP formation in COS-1 cells expressing the MC4, does not affect basal cAMP levels.
MCL0129 exhibits anxiolytic- and antidepressant-like activities in various rodent models.
| M.Wt | 546.775 | |
| Formula | C34H47FN4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chaki S, et al. J Pharmacol Exp Ther. 2003 Feb;304(2):818-26.
2. Shimazaki T, et al. Pharmacol Biochem Behav. 2005 Mar;80(3):395-400.
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