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MCL0129 tetrahydrochloride

Chemical Structure : MCL0129 tetrahydrochloride

CAS No.: 574001-66-4

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MCL0129 tetrahydrochloride (MCL-0129 tetrahydrochloride)

Catalog No.: PC-61571Not For Human Use, Lab Use Only.

MCL0129 tetrahydrochloride is a selective, potent melanocortin-4 receptor (MC4R) antagonist with Ki of 7.9 nM, without affinity for MC1 and MC3.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MCL0129 tetrahydrochloride is a selective, potent melanocortin-4 receptor (MC4R) antagonist with Ki of 7.9 nM, without affinity for MC1 and MC3.
    MCL0129 attenuates the alpha-MSH-increased cAMP formation in COS-1 cells expressing the MC4, does not affect basal cAMP levels.
    MCL0129 exhibits anxiolytic- and antidepressant-like activities in various rodent models.

    Physicochemical Properties

    M.Wt 692.607
    Formula C34H51Cl4FN4O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-1-(1-(4-fluorophenyl)-2-(4-(4-(2-methoxynaphthalen-1-yl)butyl)piperazin-1-yl)ethyl)-4-isopropylpiperazine tetrahydrochloride

    References

    1. Chaki S, et al. J Pharmacol Exp Ther. 2003 Feb;304(2):818-26.

    2. Shimazaki T, et al. Pharmacol Biochem Behav. 2005 Mar;80(3):395-400.

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