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Chemical Structure : MCUF-42
Catalog No.: PC-22560Not For Human Use, Lab Use Only.
MCUF-42 is a selective, positive allosteric modulator (PAM) of guanylyl cyclase B (GC-B) receptor, dose-dependently potentiates CNP-induced cGMP with EC50 of 0.8 uM (Emax = 86%), enhances the binding affinity between GC-B and its natural ligand C-type natriuretic peptide (CNP).
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MCUF-42 is a selective, positive allosteric modulator (PAM) of guanylyl cyclase B (GC-B) receptor, dose-dependently potentiates CNP-induced cGMP with EC50 of 0.8 uM (Emax = 86%), enhances the binding affinity between GC-B and its natural ligand C-type natriuretic peptide (CNP).
In the absence of CNP, MCUF-42 possesses no cGMP-generating activity in HEK293 GC-B cells.
MCUF-42 is a PAM without agonistic activity.
MCUF-42 binds to human GC-B with KD of 710 nM in SPR assays.
MCUF-42 (1, 5, and 10 µM) enhances the cGMP generation of CNP in human cardiac fibroblasts (HCFs).
MCUF-42 enhances CNP mediated inhibition of HCF proliferation triggered by profibrotic TGFβ1.
| M.Wt | 393.33 | |
| Formula | C19H18Cl2N2OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ma X, et al. PNAS Nexus. 2024 Jun 6;3(6):pgae225.
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