Chemical Structure : MCUF-42
CAS No.:
MCUF-42
(MCUF42)
Catalog No.: PC-22560Not For Human Use, Lab Use Only.
MCUF-42 is a selective, positive allosteric modulator (PAM) of guanylyl cyclase B (GC-B) receptor, dose-dependently potentiates CNP-induced cGMP with EC50 of 0.8 uM (Emax = 86%), enhances the binding affinity between GC-B and its natural ligand C-type natriuretic peptide (CNP).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MCUF-42 is a selective, positive allosteric modulator (PAM) of guanylyl cyclase B (GC-B) receptor, dose-dependently potentiates CNP-induced cGMP with EC50 of 0.8 uM (Emax = 86%), enhances the binding affinity between GC-B and its natural ligand C-type natriuretic peptide (CNP).
In the absence of CNP, MCUF-42 possesses no cGMP-generating activity in HEK293 GC-B cells.
MCUF-42 is a PAM without agonistic activity.
MCUF-42 binds to human GC-B with KD of 710 nM in SPR assays.
MCUF-42 (1, 5, and 10 µM) enhances the cGMP generation of CNP in human cardiac fibroblasts (HCFs).
MCUF-42 enhances CNP mediated inhibition of HCF proliferation triggered by profibrotic TGFβ1.
Physicochemical Properties
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M.Wt
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393.33
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Formula
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C19H18Cl2N2OS
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-(1-(5-(2,5-dichlorophenyl)furan-2-carbonothioyl)piperidin-4-yl)propanenitrile
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References
1. Ma X, et al. PNAS Nexus. 2024 Jun 6;3(6):pgae225.
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