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Chemical Structure : MDL72527
CAS No.: 93565-01-6
Catalog No.: PC-70176Not For Human Use, Lab Use Only.
MDL72527 is a polyamine oxidase (PAO) inhibitor that inhibits spermine oxidase and N1-acetylpolyamine oxidase with IC50 of 6.1 and 0.02 uM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $138 | In stock | |
| 25 mg | $248 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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MDL72527 is a polyamine oxidase (PAO) inhibitor that inhibits spermine oxidase and N1-acetylpolyamine oxidase with IC50 of 6.1 and 0.02 uM, respectively.
MDL72527 significantly reduces ETBF-induced chronic inflammation and proliferation in C57BL/6 mice.
MDL72527 also reduces ETBF-induced colon tumorigenesis in the multiple intestinal neoplasia mouse model.
| M.Wt | 265.2 | |
| Formula | C12H20N2 • 2HCl | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1,4-Butanediamine, N,N'-di-2,3-butadienyl-, dihydrochloride (9CI) |
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1. Moriya SS, et al. Biol Pharm Bull. 2014;37(3):475-80.
2. Chaturvedi R, et al. J Biol Chem. 2004 Sep 17;279(38):40161-73.
3. Goodwin AC, et al. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15354-9.
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