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Chemical Structure : MDOLL-0229
Catalog No.: PC-21690Not For Human Use, Lab Use Only.
MDOLL-0229 is a selective small molecule inhibitor for SARS-CoV-2 Mac1 with IC50 of 2.1 uM, inhibits coronavirus replication.
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MDOLL-0229 is a selective small molecule inhibitor for SARS-CoV-2 Mac1 with IC50 of 2.1 uM, inhibits coronavirus replication.
MDOLL-0229 is generally selective for CoV Mac1 proteins after profiling for activity against a panel of viral and human ADP-ribose binding proteins.
MDOLL-0229 inhibits replication of both MHVa prototype CoV, and SARS-CoV-2.
MDOLL-0229 is the first Mac1 targeted small molecule demonstrated to inhibit coronavirus replication in cell models.
| M.Wt | 393.50 | |
| Formula | C20H27NO5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sarah Wazir, et al. bioRxiv. 2023 Dec 27:2023.08.28.555062.
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