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ME-344

Chemical Structure : ME-344

CAS No.: 1374524-68-1

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ME-344 (ME344;ME 344;NV-344)

Catalog No.: PC-60554Not For Human Use, Lab Use Only.

ME-344 is a novel mitochondrial and mTOR inhibitor with potent anti-cancer activity, inhibits leukemia cell lines with IC50 of 70-260 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ME-344 (NV-344) is a novel mitochondrial and mTOR inhibitor with potent anti-cancer activity, inhibits leukemia cell lines with IC50 of 70-260 nM.
    ME-344 inhibits oxygen consumption rates, with specific effects on the respiratory chain, causes complex, redox-specific, and mitochondria-targeted effects in lung cancer cells.
    ME-344 reduces tumor growth in OCI-AML2 xenograft models.
    ME-344 is an active metabolite of NV-128.

    Physicochemical Properties

    M.Wt 348.40
    Formula C22H20O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (3R,4S)-3,4-bis(4-hydroxyphenyl)-8-methyl-3,4-dihydro-2H-chromen-7-ol

    References

    1. Jeyaraju DV, et al. Oncotarget. 2016 Aug 2;7(31):49777-49785.

    2. Manevich Y, et al. J Pharmacol Exp Ther. 2016 Aug;358(2):199-208.

    3. Lim SC, et al. Am J Cancer Res. 2015 Jan 15;5(2):689-701.

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