Catalog No.: PC-25014Not For Human Use, Lab Use Only.
MG-257 is a small molecule ligand of galectin-3, impedes interaction between TREM2 and galectin-3 with IC50 of 91 nM in TR-FRET assays, attenuates TREM2 signaling.
MG-257 is a small molecule ligand of galectin-3, impedes interaction between TREM2 and galectin-3 with IC50 of 91 nM in TR-FRET assays, attenuates TREM2 signaling. MG-257 has dissociation constant (Kd) of 0.15 uM for galectin-3 using FA assay, SPR KD of 0.29 uM. MG-257 can impede neuroinflammation triggered by Aβ aggregates and consequently would potentially be critical in enhancing Aβ clearance. MG-257 reduced cytokine levels in the culture medium of BV2 cells coincubated with Αβ fibrils.
