Chemical Structure : MHPAP
CAS No.:
1070954-24-3
MHPAP
Catalog No.: PC-21368Not For Human Use, Lab Use Only.
MHPAP is a potent cell-permeable anti-cytokine compound, inhibits inflammatory cytokines in monocyte/macrophage-like cells, directly binds to IκB kinase (IKK).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MHPAP is a potent cell-permeable anti-cytokine compound, inhibits inflammatory cytokines in monocyte/macrophage-like cells, directly binds to IκB kinase (IKK).
MHPAP significantly inhibits IL-6, IL-1beta, IL-8 and TNF-alpha in THP-1 cells.
MHPAP also inhibits NF-κB p65 phosphorylation in the THP-1 cells, without significant effects on c-FOS, ATF-2 and JUN phosphorylations.
MHPAP inhibits the luminescence increased in the LPS-stimulated NF-κB-Luc2 THP-1 cells.
MHPAP inhibit IL-6, IL-1beta, IL-8 and TNF-alpha significantly in LPS-stimulated PBMCs with IC50 of 0.85 and 0.87 µM for IL-6 and IL-1beta respectively.
Physicochemical Properties
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M.Wt
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325.36
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Formula
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C19H19NO4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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Methyl 2-[3-(4-hydroxyphenyl)prop-2-enoylamino]-3-phenylpropanoate
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References
1. Jae B Park. J Pharmacol Exp Ther. 2023 Nov 2:JPET-AR-2023-001830.
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