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MIND4-17

Chemical Structure : MIND4-17

CAS No.: 345989-24-4

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MIND4-17 (MIND 4-17)

Catalog No.: PC-70279Not For Human Use, Lab Use Only.

MIND4-17 is an inducer of NRF2 that selectively activates NRF2 signaling with CD value (The concentration that doubles the specific activity) of 0.18 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MIND4-17 is an inducer of NRF2 that selectively activates NRF2 signaling with CD value (The concentration that doubles the specific activity) of 0.18 uM.
    MIND4-17 covalently modifies a critical stress-sensor cysteine (C151) of the E3 ligase substrate adaptor protein KEAP1, arrests KEAP/NRF2 complex in the closed conformation in live cells.
    MIND4-17 potently represses the release of the proinflammatory cytokine IL-6 in primary mouse HD and WT microglia and astrocytes.

    Physicochemical Properties

    M.Wt 405.432
    Formula C20H15N5O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-nitro-2-{[5-(phenoxymethyl)-4-phenyl-4H-1,2,4-triazol-3-yl]thio}pyridine

    References

    1. Quinti L, et al. Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):E4676-E4685.

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