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Chemical Structure : MIPS2673
Catalog No.: PC-22690Not For Human Use, Lab Use Only.
MIPS2673 is a potent selective inhibitor of Plasmodium M1 aminopeptidase with Ki of 211 nM and 6.4 nM for PfA-M1 and PvA-M1, demonstrates antimalarial activity against a panel of drug-resistant P. falciparum strains.
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MIPS2673 is a potent selective inhibitor of Plasmodium M1 aminopeptidase with Ki of 211 nM and 6.4 nM for PfA-M1 and PvA-M1, demonstrates antimalarial activity against a panel of drug-resistant P. falciparum strains.
MIPS2673 is non-inhibitory against the PfA-M18 (Ki >500 µM) and PfAPP (Ki >40 µM) recombinant metalloaminopeptidases.
MIPS2673 shows antimalarial activity against P. falciparum 3D7 parasites with EC50 of 324 nM.
MIPS2673 inhibits the key role of PfA-M1 in haemoglobin digestion.
| M.Wt | 382.34 | |
| Formula | C18H17F3N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Giannangelo C, et al. Elife. 2024 Jul 8;13:RP92990.
2. Creek D, et al. Res Sq [Preprint]. 2024 Apr 26:rs.3.rs-3251230.
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