Chemical Structure : MIPS2673
CAS No.:
MIPS2673
(MIPS 2673)
Catalog No.: PC-22690Not For Human Use, Lab Use Only.
MIPS2673 is a potent selective inhibitor of Plasmodium M1 aminopeptidase with Ki of 211 nM and 6.4 nM for PfA-M1 and PvA-M1, demonstrates antimalarial activity against a panel of drug-resistant P. falciparum strains.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MIPS2673 is a potent selective inhibitor of Plasmodium M1 aminopeptidase with Ki of 211 nM and 6.4 nM for PfA-M1 and PvA-M1, demonstrates antimalarial activity against a panel of drug-resistant P. falciparum strains.
MIPS2673 is non-inhibitory against the PfA-M18 (Ki >500 µM) and PfAPP (Ki >40 µM) recombinant metalloaminopeptidases.
MIPS2673 shows antimalarial activity against P. falciparum 3D7 parasites with EC50 of 324 nM.
MIPS2673 inhibits the key role of PfA-M1 in haemoglobin digestion.
Physicochemical Properties
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M.Wt
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382.34
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Formula
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C18H17F3N2O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-hydroxy-N-(2-(hydroxyamino)-2-oxo-1-(3',4',5'-trifluoro-[1,1'-biphenyl]-4-yl)ethyl)-2-methylpropanamide
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References
1. Giannangelo C, et al. Elife. 2024 Jul 8;13:RP92990.
2. Creek D, et al. Res Sq [Preprint]. 2024 Apr 26:rs.3.rs-3251230.
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