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MJN110

Chemical Structure : MJN110

CAS No.: 1438416-21-7

MJN110 (MJN 110, MJN-110)

Catalog No.: PC-60707Not For Human Use, Lab Use Only.

MJN110 (MJN-110) is a potent, selective, and orally active MAGL inhibitor with IC50 of 2.1 nM (2-AG hydrolysis).

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Biological Activity

MJN110 (MJN-110) is a potent, selective, and orally active MAGL inhibitor with IC50 of 2.1 nM (2-AG hydrolysis).
MJN110 wekaly inhibits ABHD6, with excellent selectivity over FAAH and other serine hydrolases.
MJN110 inactivates hMAGL with IC50 of 9.1 nM, attenuates established mechanical allodynia in rat model of diabetic neuropathy.

Physicochemical Properties

M.Wt 462.327
Formula C22H21Cl2N3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2,5-dioxopyrrolidin-1-yl 4-(bis(4-chlorophenyl)methyl)piperazine-1-carboxylat

References

1. Niphakis MJ, et al. ACS Chem Neurosci. 2013 Sep 18;4(9):1322-32.

2. Parker LA, et al. Psychopharmacology (Berl). 2015 Feb;232(3):583-93.

3. Ignatowska-Jankowska B, J Pharmacol Exp Ther. 2015 May;353(2):424-32. et al.

4. Wilkerson JL, et al. J Pharmacol Exp Ther. 2016 Apr;357(1):145-56.

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