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Chemical Structure : MK-0343
Catalog No.: PC-62091Not For Human Use, Lab Use Only.
MK-0343 (MRK-409) is a potent, α2/3 subtype selective, partial GABAA receptor agonist, shows greater agonist efficacy at the α3 over α1 subtypes.
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MK-0343 (MRK-409) is a potent, α2/3 subtype selective, partial GABAA receptor agonist, shows greater agonist efficacy at the α3 over α1 subtypes; readily penetrates the brain in rats and occupies the benzodiazepine site of GABA(A) receptors with an Occ(50) of 2.2 mg/kg p.o. and a corresponding plasma EC50 of 115 ng/mL; produces anxiolytic-like activity in rodent and primate unconditioned and conditioned models of anxiety.
| M.Wt | 397.39 | |
| Formula | C19H17F2N7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Atack JR, et al. J Psychopharmacol. 2011 Mar;25(3):314-28.
2. de Haas SL, et al. J Psychopharmacol. 2008 Jan;22(1):24-32.
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