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Chemical Structure : MK-0608
CAS No.: 443642-29-3
Catalog No.: PC-60960Not For Human Use, Lab Use Only.
MK-0608 is a nucleoside analogue that shows potent inhibition for replication of several mosquito-borne flaviviruses including DENV and ZIKV.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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MK-0608 is a nucleoside analogue that shows potent inhibition for replication of several mosquito-borne flaviviruses including DENV and ZIKV.
MK-0608 also inhibits viral RNA replication in the subgenomic HCV genotype 1b replicon with EC50 of 0.3 uM, inhibits ZIKV viral polymerase both in vitro and in vivo.
| M.Wt | 280.284 | |
| Formula | C12H16N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2R,3R,4R,5R)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3-methyltetrahydrofuran-3,4-diol |
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1. Schul W, et al. J Infect Dis. 2007 Mar 1;195(5):665-74.
2. Carroll SS, et al. Antimicrob Agents Chemother. 2009 Mar;53(3):926-34.
3. Zmurko J, et al. PLoS Negl Trop Dis. 2016 May 10;10(5):e0004695.
4. Eyer L, et al. J Virol. 2017 Aug 16. pii: JVI.01028-17.
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