Chemical Structure : MK-1088
CAS No.:
2433765-51-4
MK-1088
(MK1088)
Catalog No.: PC-26707Not For Human Use, Lab Use Only.
MK-1088 is a potent, selective dual adenosine A2A receptor (A2AR) and A2B receptor (A2BR) antagonist with Ki values of 0.31 nM and 5.3 nM for human A2AR and A2BR respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MK-1088 is a potent, selective dual adenosine A2A receptor (A2AR) and A2B receptor (A2BR) antagonist with Ki values of 0.31 nM and 5.3 nM for human A2AR and A2BR respectively.
MK-1088 displays >100-fold selectivity over A1R and A3R versus A2AR.
MK-1088 exhibits high affinity for mouse A2AR and A2BR with Ki of 3.2 nM and 28 nM respectively.
MK-1088 shows potential to reverse adenosine-mediated suppression of tumor immune surveillance as either a single-agent treatment or in combination with other immunotherapy agents such as anti-PD-1/PD-L1 monoclonal antibodies.
Physicochemical Properties
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M.Wt
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468.54
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Formula
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C23H29FN8O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-(4-((2S,5R)-5-(5-Amino-9-fluoro-8-methoxy-[1,2,4]triazolo[1,5-c]quinazolin-2-yl)-2-methylpiperidin-1-yl)-1H-pyrazol-1-yl)-2-methylpropan-2-ol
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References
1. Zhang Y, et al. J Med Chem. 2026 May 5. doi: 10.1021/acs.jmedchem.5c03405.
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