Chemical Structure : MK-4815
CAS No.:
84210-35-5
MK-4815
(MK4815)
Catalog No.: PC-23027Not For Human Use, Lab Use Only.
MK-4815 is an orally active small molecule with antimalarial activity, inhibits P. falciparum 3D7 growth with IC50 of 0.03 ug/mL, inhibits falcilysin (FLN) proteolytic activity.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MK-4815 is an orally active small molecule with antimalarial activity, inhibits P. falciparum 3D7 growth with IC50 of 0.03 ug/mL, inhibits falcilysin (FLN) proteolytic activity.
MK-4815 is as potent as chloroquine against the chloroquine-sensitive NF54 strain of P. falciparum (IC50s, 38 and 35 ng/ml, respectively) and more potent than chloroquine against the chloroquine-, pyrimethamine-, and mefloquine-resistant Dd2 strain (IC50s, 40 and 70 ng/ml, respectively).
MK-4815 has broad-spectrum and potent activity against the entire panel, particularly with the potent IC50s for the K1, V1/S, and FCB strains of parasite.
MK-4815 is orally active in a P. berghei mouse model of acute malaria.
Physicochemical Properties
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M.Wt
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235.37
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Formula
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C15H25NO
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-aminomethyl-3,5-di-tert-butylphenol
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References
1. Powles MA, et al. Antimicrob Agents Chemother. 2012 May;56(5):2414-9.
2. Wirjanata G, et al. Cell Chem Biol. 2024 Apr 18;31(4):743-759.e8.
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