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Chemical Structure : MK-5046
CAS No.: 1022152-70-0
Catalog No.: PC-38792Not For Human Use, Lab Use Only.
MK-5046 a potent, selective small molecule agonist of BRS-3 (bombesin receptor subtype-3) with Ki and EC50 values of 3.7 and 14 nM (hBRS-3), respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $488 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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MK-5046 a potent, selective small molecule agonist of BRS-3 (bombesin receptor subtype-3) with Ki and EC50 values of 3.7 and 14 nM (hBRS-3), respectively.
MK-5046 exhibits high selectivity in a screen of >100 receptors, ion channels, and enzymes.
MK-5046 shows potent activities across a range of species, including rat, mouse, dog and rhesus.
MK-5046 causes mechanism-based, dose-dependent reductions in food intake and body weight.
| M.Wt | 444.381 | |
| Formula | C20H18F6N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2S)-1,1,1-trifluoro-2-[4-(1H-pyrazol-1-yl)phenyl]-3-(4-{[1-(trifluoromethyl)cyclopropyl]methyl}-1H-imidazol-2-yl)propan-2-ol |
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1. Guan XM, et al. J Pharmacol Exp Ther. 2011 Feb;336(2):356-64.
2. Sebhat IK, et al. ACS Med Chem Lett. 2010 Oct 18;2(1):43-7.
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