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Chemical Structure : MK-5108
CAS No.: 1010085-13-8
Catalog No.: PC-43431Not For Human Use, Lab Use Only.
MK-5108 (VX-689) is a potent, highly selective Aurora-A kinase inhibitor with IC50 of 0.064 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | $548 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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MK-5108 (VX-689) is a potent, highly selective Aurora-A kinase inhibitor with IC50 of 0.064 nM, displays robust selectivity against Aurora-B (220-fold) and Aurora-C (190-fold) in the biochemical assays.
MK-5108 (VX-689) also exhibits high selectivity for Aurora-A over a panel of 233 kinases, only one kinase (TrkA) with <100-fold selectivity.
MK-5108 (VX-689) inhibits the growth of multiple human cancer cell lines in vitro and in human cancer xenograft models.
MK-5108 (VX-689) MK-5108 significantly enhanced the efficacy of docetaxel without increasing its toxicity.
| M.Wt | 461.94 | |
| Formula | C22H21ClFN3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 6.4 mg/mL (Need warming) |
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| Chemical Name/SMILES |
Cyclohexanecarboxylic acid, 4-(3-chloro-2-fluorophenoxy)-1-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]-, trans- |
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1. Shimomura T, et al. Mol Cancer Ther. 2010 Jan;9(1):157-66.
2. Kretzner L, et al. Cancer Res. 2011 Jun 1;71(11):3912-20.
3. Shan W, et al. Clin Cancer Res. 2012 Jun 15;18(12):3352-65.
4. Chefetz I, et al. Cell Cycle. 2011 Jul 1;10(13):2206-14.
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