Chemical Structure : MK-7762
CAS No.:
2706576-88-5
MK-7762
(TBD09, MK7762)
Catalog No.: PC-25987Not For Human Use, Lab Use Only.
MK-7762 (TBD09) is a new broadly active oxazolidinone Mycobacterium tuberculosis (Mtb) inhibitor with MIC95 of 0.93 uM, inhibits the mycobacterial ribosome.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MK-7762 (TBD09) is a new broadly active oxazolidinone Mycobacterium tuberculosis (Mtb) inhibitor with MIC95 of 0.93 uM, inhibits the mycobacterial ribosome.
MK-7762 shows no inhibition in a panel of 106 off-targets except for monoamine oxidase-B (IC50=6.9 uM).
MK-7762 showsminimal inhibition of MPS (half-maximal effective concentration (EC50) of 98 µM) compared to linezolid (EC50 of 16 µM), suggesting a low risk for mitochondrial toxicity in humans compared to linezolid.
MK-7762 has a more potent minimum bactericidal concentration (MBC) than that of linezolid with an observed MBC99 of 18.1 µM compared to 52.7 µM.
MK-7762 is active against a wide range of diverse drug-sensitive and drug-resistant clinical isolates and showed similar bactericidal activity as linezolid.
Physicochemical Properties
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M.Wt
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419.40
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Formula
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C16H19F2N3O6S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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methyl (S)-((3-(4-(1,1-dioxidothiomorpholino)-3,5-difluorophenyl)-2-oxooxazolidin-5-yl)methyl)carbamate
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References
1. Crowley BM, et al. Nat Med. 2026 Jan 13. doi: 10.1038/s41591-025-04164-x.
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