Chemical Structure : MK-7845
CAS No.:
2952554-69-5
MK-7845
(MK7845)
Catalog No.: PC-21803Not For Human Use, Lab Use Only.
MK-7845 is a potent, reversible covalent SARS-CoV-2 3CLPro inhibitor with IC50 of 8.7 nM, inhibits wild-type SARS-CoV-2 3CLPro in SARS-CoV-2 reporter replicon assay in A549 cells with IC50 of 15 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MK-7845 is a potent, reversible covalent SARS-CoV-2 3CLPro inhibitor with IC50 of 8.7 nM, inhibits wild-type SARS-CoV-2 3CLPro in SARS-CoV-2 reporter replicon assay in A549 cells with IC50 of 15 nM.
MK-7845 isplays 82-fold to >1000-fold selectivity agianst a panel of host-cell proteases.
MK-7845 otently inhibits P132H mutant 3CLPro present in the Omicron variant with IC50 of 15 nM.
MK-7845 hows similar activity against the parental WA1/2020, Delta, and Omicron strains of the virus with EC50 value of 215 nM-444 nM.
MK-7845 showed significant and dose-dependent reductions in viral load beginning at 250 mg/kg in mouse model of SARS-CoV-2 infection.
Physicochemical Properties
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M.Wt
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516.59
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Formula
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C24H38F2N4O6
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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methyl ((S)-1-((1S,3aR,6aS)-1-(((S)-6,6-difluoro-1-(methylamino)-1,2-dioxoheptan-3-yl)carbamoyl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate
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References
1. Valerie W Shurtleff, et al. J Med Chem. 2024 Feb 16. doi: 10.1021/acs.jmedchem.3c02248.
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