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Chemical Structure : MK-8722
CAS No.: 1394371-71-1
Catalog No.: PC-60137Not For Human Use, Lab Use Only.
MK-8722 is a potent, selective, allosteric pan-AMPK activator with EC50 of 1-60 nM for all 12 mammalian AMPK isoforms.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $138 | In stock | |
| 25 mg | $228 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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MK-8722 is a potent, selective, allosteric pan-AMPK activator with EC50 of 1-60 nM for all 12 mammalian AMPK isoforms.
MK-8722 exhibits higher affinity for β1-containing (1-6 nM) versus β2-containing (15-63 nM) pAMPK complexes.
MK-8722 increases glucose uptake into skeletal muscle in vitro and in vivo, but induces cardiac hypertrophy.
| M.Wt | 449.891 | |
| Formula | C24H20ClN3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(3R,3aR,6R,6aR)-6-((5-([1,1'-Biphenyl]-4-yl)-6-chloro-1H-imidazo[4,5-b]pyridin-2-yl)oxy)hexahydrofuro[3,2-b]furan-3-ol |
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1. Myers RW, et al. Science. 2017 Aug 4;357(6350):507-511.
2. Danqing Feng, et al. ACS Med. Chem. Lett. DOI: 10.1021/acsmedchemlett.7b00417
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