MK6-83 | TRPML1 agonist | Probechem Biochemicals

Chemical Structure : MK6-83

CAS No.: 1062271-24-2

MK6-83 (MK 6-83)

Catalog No.: PC-21060Not For Human Use, Lab Use Only.

MK6-83 is a specific transient receptor potential mucolipin -1 (TRPML1/MCOLN1) agonist, activates the entire endosomal TRPML1 current in DMD myocytes with EC50 of 285 nM.

Packing	Price	Stock
25 mg	$198	In stock
50 mg	$298	In stock
100 mg	$498	In stock
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Biological Activity

MK6-83 is a specific transient receptor potential mucolipin -1 (TRPML1/MCOLN1) agonist, activates the entire endosomal TRPML1 current in DMD myocytes with EC50 of 285 nM.
MK6-83 is more potent than ML-SA1.
MK6-83 arrests autophagic flux by perturbing fusion between autophagosomes and lysosomes.

Physicochemical Properties

M.Wt	336.47
Formula	C16H20N2O2S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide

References

1. Morelli MB, et al. Cancers (Basel). 2019 Apr 12;11(4):525.

2. Jiansong Qi, et al. Autophagy. 2021 Dec;17(12):4401-4422.

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MK6-83 (MK 6-83)

Biological Activity

Physicochemical Properties

References

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