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Chemical Structure : MKC8866
CAS No.: 1338934-59-0
Catalog No.: PC-62739Not For Human Use, Lab Use Only.
MKC8866 (ORIN1001) is a spectific small molecule inhibitor of mammalian IRE1 RNase activity with IC50 of 0.29 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $188 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $498 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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MKC8866 (ORIN1001) is a spectific small molecule inhibitor of mammalian IRE1 RNase activity with IC50 of 0.29 uM.
ORIN1001 (MKC8866) prevents the recombinant IRE1 protein from cleaving the synthetic XBP1 RNA probe, but has no effect on RNase A, RNase L and yeast IRE1 (scIRE1).
ORIN1001 (MKC8866) suppresses growth of patient-derived tumors with high MYC expression.|
ORIN1001 (MKC8866) potently sensitizes the tumors to the apoptotic and proliferation inhibitory effects of chemotherapy in vivo.
| M.Wt | 361.35 | |
| Formula | C18H19NO7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
7-hydroxy-6-methoxy-4-methyl-3-(2-morpholino-2-oxoethyl)-2-oxo-2H-chromene-8-carbaldehyde |
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1. Zhao N, et al. J Clin Invest. 2018 Feb 26. pii: 95873.
2. Sanches M, et al. Nat Commun. 2014 Aug 28;5:4202.
3. Logue SE, et al. Nat Commun. 2018 Aug 15;9(1):3267.
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