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MKC9989

Chemical Structure : MKC9989

CAS No.: 1338934-20-5

MKC9989 (MKC 9989, MKC-9989)

Catalog No.: PC-62740Not For Human Use, Lab Use Only.

MKC9989 is a specific small molecule inhibitor of IRE1α Rnase (Kd=0.84 uM) with potency against the splicing of XBP1 mRNA (EC50=0.33 uM)..

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MKC9989 is a specific small molecule inhibitor of IRE1α Rnase (Kd=0.84 uM) with potency against the splicing of XBP1 mRNA (EC50=0.33 uM).

Physicochemical Properties

M.Wt 336.34
Formula C17H20O7
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

7-hydroxy-6-methoxy-3-(2-(2-methoxyethoxy)ethyl)-4-methyl-2-oxo-2H-chromene-8-carbaldehyde

References

1. Sanches M, et al. Nat Commun. 2014 Aug 28;5:4202.

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