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Chemical Structure : ML-290
CAS No.: 1482500-76-4
Catalog No.: PC-70187Not For Human Use, Lab Use Only.
ML-290 (ML290) is a potent and selective small-molecule agonist of hRXFP1 with EC50 of 94 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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ML-290 (ML290) is a potent and selective small-molecule agonist of hRXFP1 with EC50 of 94 nM.
ML-290 displays >15-fold selectivity over RXFP2 (IC50>15 uM).
ML-290 shows similar efficacy as the natural hormone in functional assays, and increases intracellular cAMP and induces VEGF expression (2.8-fold at 250 nM).
ML-290 has as excellent in vitro ADME profile and in vivo PK properties; a very useful tool for the study of RXFP1 activation in pre-clinical disease models of heart failure and other diseases.
| M.Wt | 506.5 | |
| Formula | C24H21F3N2O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-[[2-(1-Methylethoxy)benzoyl]amino]-N-[3-[(trifluoromethyl)sulfonyl]phenyl]benzamide |
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1. Diepenhorst NA, et al. J Biol Chem. 2014 Dec 12;289(50):34938-52.
2. Xiao J, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
3. Kocan M, et al. Sci Rep. 2017 Jun 7;7(1):2968.
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