ML-9 free base | MLCK inhibitor | Probechem Biochemicals

You are here:Home-Chemical Inhibitors & Agonists-Cytoskeleton/Cell Adhesion Molecules-Myosin-ML-9 free base

Chemical Structure : ML-9 free base

ML-9 free base (MLCK inhibitor)

Catalog No.: PC-23162Not For Human Use, Lab Use Only.

ML-9 is a potent, ATP-competitive myosin light chain kinase (MLCK) inhibitor with Ki of 3.8 uM, inhibits Store-operated Ca2+ entry (SOCE) in a variety of cell lines.

Packing	Price	Stock	Quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ML-9 is a potent, ATP-competitive myosin light chain kinase (MLCK) inhibitor with Ki of 3.8 uM, inhibits Store-operated Ca2+ entry (SOCE) in a variety of cell lines.
ML-9 also inhibits PKA and PKC with Ki of 32 uM and 54 uM.
ML-9 inhibits STIM1-plasma membrane interactions and inhibits TRPC6 channels via a mechanism independent of inhibition of MLCK activity.

Physicochemical Properties

M.Wt	416.28
Formula	C15H17IN2O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-((5-iodonaphthalen-1-yl)sulfonyl)-1,4-diazepane

References

1. Shi J, et al. Br J Pharmacol. 2007 Sep;152(1):122-31.

2. Várnai P, et al. Trends Pharmacol Sci. 2009 Mar;30(3):118-28.

3. Ito S, et al. Eur J Pharmacol. 2004 Feb 23;486(3):325-33.

Overnight Delivery
Fast & Safe Delivery Worldwide
Rewards Program

About Us

Our Services

Site Map

Join with Us
Product Use Citations

Pharmacological Glossary Abbreviations

Abbreviations

Quality Manual

Inquiry Form
How to Order

Terms & Conditions

Credit Card Payment

Shipping Rates & Policies

Privacy Policy
sales@probechem.com