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Chemical Structure : ML-9 free base
Catalog No.: PC-23162Not For Human Use, Lab Use Only.
ML-9 is a potent, ATP-competitive myosin light chain kinase (MLCK) inhibitor with Ki of 3.8 uM, inhibits Store-operated Ca2+ entry (SOCE) in a variety of cell lines.
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ML-9 is a potent, ATP-competitive myosin light chain kinase (MLCK) inhibitor with Ki of 3.8 uM, inhibits Store-operated Ca2+ entry (SOCE) in a variety of cell lines.
ML-9 also inhibits PKA and PKC with Ki of 32 uM and 54 uM.
ML-9 inhibits STIM1-plasma membrane interactions and inhibits TRPC6 channels via a mechanism independent of inhibition of MLCK activity.
| M.Wt | 416.28 | |
| Formula | C15H17IN2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Shi J, et al. Br J Pharmacol. 2007 Sep;152(1):122-31.
2. Várnai P, et al. Trends Pharmacol Sci. 2009 Mar;30(3):118-28.
3. Ito S, et al. Eur J Pharmacol. 2004 Feb 23;486(3):325-33.
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