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Chemical Structure : ML141
CAS No.: 71203-35-5
Catalog No.: PC-43180Not For Human Use, Lab Use Only.
ML141 (CID-2950007) is a potent, selective, reversible non-competitive inhibitor of Cdc42 GTPase with IC50 of 200 nM in biochemical assays, shows no appreciable inhibitory activity against Rac1, Rab2, Rab7 or Ras.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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ML141 (CID-2950007) is a potent, selective, reversible non-competitive inhibitor of Cdc42 GTPase with IC50 of 200 nM in biochemical assays, shows no appreciable inhibitory activity against Rac1, Rab2, Rab7 or Ras.
ML141 also exhibits IC50 of 2.6 and 5.4 uM for Cdc42 wild type and activated mutant in the primary HTS bead-based assays.
ML141 enhances G-CSF-induced hematopoietic stem and progenitor cell mobilization, also significantly protects neuroblastoma cells from metformin-induced apoptosis.
| M.Wt | 407.4854 | |
| Formula | C22H21N3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 55 mg/mL |
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| Chemical Name/SMILES |
Benzenesulfonamide, 4-[4,5-dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]- |
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1. Surviladze Z, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
2. Chen HY, et al. EMBO Mol Med. 2013 May;5(5):723-36.
3. Zhang Y, et al. Neuroscience. 2015 Mar 19;289:381-91.
4. Chen C, et al. Int J Hematol. 2015 Jan;101(1):5-12.
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