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Chemical Structure : ML146
Catalog No.: PC-49812Not For Human Use, Lab Use Only.
ML146 (ML-146, Pubmed CID-1088438) is a selective small molecule NOD1 inhibitor with IC50 of 1.5 uM in NOD1 agonist-stimulated NF-κB reporter assay in HEK293T cells.
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ML146 (ML-146, Pubmed CID-1088438) is a selective small molecule NOD1 inhibitor with IC50 of 1.5 uM in NOD1 agonist-stimulated NF-κB reporter assay in HEK293T cells.
ML146 displays > 8-fold selectivity over NOD2 and >29- fold over TNFα.
ML146 inhibits NOD1 mediated IL-8 secretion with IC50 of 3.43 uM against γ-tri-DAP induction of human breast cancer epithelial cell lines MCF-7 expressing NOD1.
| M.Wt | 370.47 | |
| Formula | C19H22N4O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Magnuson G, et al. [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–.
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