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ML146

Chemical Structure : ML146

CAS No.: 1164540-96-8

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ML146 (ML 146)

Catalog No.: PC-49812Not For Human Use, Lab Use Only.

ML146 (ML-146, Pubmed CID-1088438) is a selective small molecule NOD1 inhibitor with IC50 of 1.5 uM in NOD1 agonist-stimulated NF-κB reporter assay in HEK293T cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ML146 (ML-146, Pubmed CID-1088438) is a selective small molecule NOD1 inhibitor with IC50 of 1.5 uM in NOD1 agonist-stimulated NF-κB reporter assay in HEK293T cells.
ML146 displays > 8-fold selectivity over NOD2 and >29- fold over TNFα.
ML146 inhibits NOD1 mediated IL-8 secretion with IC50 of 3.43 uM against γ-tri-DAP induction of human breast cancer epithelial cell lines MCF-7 expressing NOD1.

Physicochemical Properties

M.Wt 370.47
Formula C19H22N4O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

7-[(E)-but-2-enyl]-3-methyl-8-(3-phenylpropylsulfanyl)purine-2,6-dione

References

1. Magnuson G, et al. [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–.

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