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Chemical Structure : ML154
CAS No.: 1345964-89-7
Catalog No.: PC-61554Not For Human Use, Lab Use Only.
ML154 (NCGC00185684) is a potent, selective, brain penetrant NPSR (Neuropeptide S receptor, GPR154) antagonist with IC50 of 22.1 nM and 36.5 nM in Ca2+ assay and cAMP assay, respectively.
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|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $428 | In stock | |
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ML154 (NCGC00185684) is a potent, selective, brain penetrant NPSR (Neuropeptide S receptor, GPR154) antagonist with IC50 of 22.1 nM and 36.5 nM in Ca2+ assay and cAMP assay, respectively.
ML154 shows biased antagonist properties, and preferentially blocks ERK-phosphorylation over intracellular cAMP or calcium responses to NPS in vitro.
ML154 blocks alcohol-induced ERK-phosphorylation in the rat central amygdala, also decreases operant alcohol self-administration, and lowers motivation for alcohol reward in rats.
| M.Wt | 545.47 | |
| Formula | C29H26N2PS.Br | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-cinnamyl-3-(diphenylphosphorothioyl)-2-methyl-2,3-dihydroimidazo[1,2-a]pyridin-1-ium |
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1. Thorsell A, et al. J Neurosci. 2013 Jun 12;33(24):10132-42.
2. Patnaik S, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
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