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ML188

Chemical Structure : ML188

CAS No.: 1417700-13-0

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ML188 (ML 188, Jun8-48-1)

Catalog No.: PC-72195Not For Human Use, Lab Use Only.

ML188 (ML 188, Jun8-48-1) is a potent, selective, noncovalent small molecule inhibitor of the SARS-CoV 3CL protease (3CLpro) with IC50 of 1.5 uM, inactive against PLpro.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ML188 (ML 188, Jun8-48-1) is a potent, selective, noncovalent small molecule inhibitor of the SARS-CoV 3CL protease (3CLpro) with IC50 of 1.5 uM, inactive against PLpro.
ML188 displays antiviral activity against SARS-CoV Urbani infected Vero E6 cells with EC50 of 12.9 uM.
ML188 exhibits no significant activity against 68 discrete GPCRs, ion channels and transporters, has excellent aqueous solubility up to 95 ug/mL or 219 uM.

Physicochemical Properties

M.Wt 433.552
Formula C26H31N3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Month
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Solubility

Chemical Name/SMILES

References

1. Jacobs J, et al. J Med Chem. 2013 Jan 24;56(2):534-46.

2. Turlington M, et al. Bioorg Med Chem Lett. 2013 Nov 15;23(22):6172-7.

3. Lockbaum GJ, et al. Viruses. 2021 Jan 25;13(2):174. doi: 10.3390/v13020174.

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