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ML191

Chemical Structure : ML191

CAS No.: 931695-79-3

ML191 (ML-191;CCG-152883)

Catalog No.: PC-35027Not For Human Use, Lab Use Only.

ML191 (CCG-152883) is a potent, selective GPR55 antagonist with 160 nM potency for GPR55 and >100-fold selectivity against GPR35, CB1 and CB2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ML191 (CCG-152883) is a potent, selective GPR55 antagonist with 160 nM potency for GPR55 and >100-fold selectivity against GPR35, CB1 and CB2.
ML191 (CCG-152883) inhibits LPI- mediated ERK1/2 phosphorylation with IC50 of 0.4 uM.
ML191 (CCG-152883) inhibits trafficking induced by 10 μM LPI in the β-arrestin trafficking assay with IC50 of 1.08 uM.

Physicochemical Properties

M.Wt 403.482
Formula C24H25N3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-phenyl-3-(1-(1-(p-tolyl)cyclopropane-1-carbonyl)piperidin-4-yl)-1,3,4-oxadiazol-2(3H)-one

References

1. Heynen-Genel S, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

2. Kotsikorou E, et al. Biochemistry. 2013 Dec 31;52(52):9456-69.

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