ML197 |CAS:1222891-88-4 Probechem Biochemicals

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Chemical Structure : ML197

ML197 (NCGC00185963;ML 197)

Catalog No.: PC-63477Not For Human Use, Lab Use Only.

ML197 (NCGC00185963) is a potent, selective small molecule inhibitor of Cdc2-like kinases (CLK) and DYRK with IC50 of 96/40/206 nM for CLK1/CLK4/Dyrk1A, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ML197 (NCGC00185963) is a potent, selective small molecule inhibitor of Cdc2-like kinases (CLK) and DYRK with IC50 of 96/40/206 nM for CLK1/CLK4/Dyrk1A, respectively.
ML197 inhibits CLK2, CLK3 and Dyrk1B with IC50 of 1327, 7448 and 1510 nM.
ML197 extends intracellular NKX3.1 half-life in LNCaP prostate cancer cells;

Physicochemical Properties

M.Wt	376.434
Formula	C20H16N4O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(benzo[d][1,3]dioxol-5-yl)-N-((2-methylthiazol-4-yl)methyl)quinazolin-4-amine

References

1. Rosenthal AS, et al. Bioorg Med Chem Lett. 2011 May 15;21(10):3152-8.

2. Ewton DZ, et al. Mol Cancer Ther. 2011 Nov;10(11):2104-14.

3. Rosenthal AS, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

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ML197 (NCGC00185963;ML 197)

Biological Activity

Physicochemical Properties

References

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