Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : ML197
Catalog No.: PC-63477Not For Human Use, Lab Use Only.
ML197 (NCGC00185963) is a potent, selective small molecule inhibitor of Cdc2-like kinases (CLK) and DYRK with IC50 of 96/40/206 nM for CLK1/CLK4/Dyrk1A, respectively.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
ML197 (NCGC00185963) is a potent, selective small molecule inhibitor of Cdc2-like kinases (CLK) and DYRK with IC50 of 96/40/206 nM for CLK1/CLK4/Dyrk1A, respectively.
ML197 inhibits CLK2, CLK3 and Dyrk1B with IC50 of 1327, 7448 and 1510 nM.
ML197 extends intracellular NKX3.1 half-life in LNCaP prostate cancer cells;
| M.Wt | 376.434 | |
| Formula | C20H16N4O2S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Rosenthal AS, et al. Bioorg Med Chem Lett. 2011 May 15;21(10):3152-8.
2. Ewton DZ, et al. Mol Cancer Ther. 2011 Nov;10(11):2104-14.
3. Rosenthal AS, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
