Catalog No.: PC-43288Not For Human Use, Lab Use Only.
ML204 is a potent, selective antagonist of TRPC4 and TRPC5 channels, inhibits TRPC4β-mediated intracellular Ca(2+) rise with IC50 of 0.96 uM, exhibits 19-fold selectivity against TRPC6 channel.
ML204 is a potent, selective antagonist of TRPC4 and TRPC5 channels, inhibits TRPC4β-mediated intracellular Ca(2+) rise with IC50 of 0.96 uM, exhibits 19-fold selectivity against TRPC6 channel.
ML204 blocks TRPC4β currents activated through either μ-opioid receptor stimulation (50 nm DAMGO, IC50=3.55 uM) or intracellular dialysis of GTPγS (IC50=2.85 uM).
ML204 shows no appreciable block by 10-20 uM for TRPV1, TRPV3, TRPA1, and TRPM8, as well as KCNQ2 and Nav Channels.
ML204 also inhibits TRPC5 channel currents activated through co-stimulation of Gi/o and Gq/11 signaling by μ-opioid and M3-like muscarinic receptors.
Physicochemical Properties
M.Wt
226.3168
Formula
C15H18N2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: ≥ 37 mg/mL
Chemical Name/SMILES
Quinoline, 4-methyl-2-(1-piperidinyl)-
References
1. Miller M, et al. J Biol Chem. 2011 Sep 23;286(38):33436-46.
2. Zhang L, et al. Neuropharmacology. 2013 Sep;72:106-15.
3. Carson C, et al. PLoS One. 2015 Jun 22;10(6):e0127498.
4. Alawi KM, et al. Ann Rheum Dis. 2017 Jan;76(1):252-260.
