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ML239

Chemical Structure : ML239

CAS No.: 1378872-36-6

ML239 (ML 239, CID49843203)

Catalog No.: PC-62221Not For Human Use, Lab Use Only.

ML239 is a selective small molecule inhibitor of breast cancer stem cells with IC50 of 1.18 uM, displays >23-fold selective inhibition of the breast CSC-like cell line over the isogenic control cell line.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ML239 is a selective small molecule inhibitor of breast cancer stem cells (CSCs) with IC50 of 1.18 uM, displays >23-fold selective inhibition of the breast CSC-like cell line over the isogenic control cell line.
ML239 alters the expression of genes in the MAPK, NF-κB, and inflammatory cytokine pathways.
ML239 most likely acts through activation of fatty acid desaturase 2 (FADS2).

Physicochemical Properties

M.Wt 346.592
Formula C13H10Cl3N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(2,4,6-trichlorophenoxy)-acetic acid, (2E)-2-(1H-pyrrol-2-ylmethylene)hydrazide

References

1. Rees MG, et al. Nat Chem Biol. 2016 Feb;12(2):109-16.

2. Carmody LC, et al. J Biomol Screen. 2012 Oct;17(9):1204-10.

3. Germain AR, et al. Bioorg Med Chem Lett. 2012 May 15;22(10):3571-4.

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