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ML300

Chemical Structure : ML300

CAS No.: 1473419-49-6

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ML300 (ML 300)

Catalog No.: PC-72197Not For Human Use, Lab Use Only.

ML300 (ML 300) is a potent, selective, noncovalent inhibitor of the SARS-CoV 3CL protease (3CLpro) with IC50 of 4.11 uM, inhibits SARS-CoV-2 3CLpro with IC50 of 4.99 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ML300 (ML 300) is a potent, selective, noncovalent inhibitor of the SARS-CoV 3CL protease (3CLpro) with IC50 of 4.11 uM, inhibits SARS-CoV-2 3CLpro with IC50 of 4.99 uM.

    Physicochemical Properties

    M.Wt 431.514
    Formula C23H21N5O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(4-(2-(1H-benzo[d][1,2,3]triazol-1-yl)-N-(thiophen-3-ylmethyl)acetamido)phenyl)cyclopropanecarboxamide

    References

    1. Han SH, et al. J Med Chem. 2021 Aug 4:acs.jmedchem.1c00598.

    2. Turlington M, et al. Bioorg Med Chem Lett. 2013 Nov 15;23(22):6172-7.

    3. Turlington M, et al. 2012 Apr 9 [updated 2013 Mar 14]. In: Probe Reports from the NIH Molecular Libraries Program [Internet].

    4. Sang Hoon Han, et al. J Med Chem. 2021 Aug 4;acs.jmedchem.1c00598.

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