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ML307

Chemical Structure : ML307

CAS No.:

ML307 (ML-307)

Catalog No.: PC-38264Not For Human Use, Lab Use Only.

ML307 is a potent, sub-micromolar (IC50=781 nM), first-in-class, small molecule inhibitor of Ubc13 enzyme activity, >128-fold selective against Caspase-3 and Bfl-1.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ML307 is a potent, sub-micromolar (IC50=781 nM), first-in-class, small molecule inhibitor of Ubc13 enzyme activity, >128-fold selective against Caspase-3 and Bfl-1.

    Physicochemical Properties

    M.Wt 522.094
    Formula C28H36ClN7O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (R)-N-((1-(3-chlorobenzyl)piperidin-4-yl)methyl)-1-(6,7,8,9-tetrahydropyrido[1,2-e]purin-4-yl)piperidine-3-carboxamide

    References

    1. Robert Ardecky, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. 2012.

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