ML315 | CLK inhibitor | Probechem Biochemicals

Chemical Structure : ML315

ML315 (ML 315)

Catalog No.: PC-20756Not For Human Use, Lab Use Only.

ML315 is a small molecule inhibitor of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases with IC50 of 68, 231, >10,000, 68, 282 and 1156 nM for CLK1/2/3/4 and DYRK1/2, respectively.

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Biological Activity

Physicochemical Properties

M.Wt	374.22
Formula	C18H13Cl2N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ClC1=CC(Cl)=CC(CNC2=NC=NC=C2C3=CC=C(OCO4)C4=C3)=C1

References

1. Coombs TC, et al. Bioorg Med Chem Lett. 2013 Jun 15;23(12):3654-61.

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ML315 (ML 315)

Biological Activity

Physicochemical Properties

References

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